Facile and effective pretreatment using stop and go extraction tips for LC-MS/MS analysis of trace amounts of DNA adducts.

نویسندگان

  • Hiroya Murakami
  • Rieko Kawamura
  • Takayoshi Sakakibara
  • Yukihiro Esaka
  • Yasushi Ishihama
  • Bunji Uno
چکیده

The preparation and application of a stop and go extraction tip (StageTip) used for pre-purification of sample solutions for LC-MS/MS analysis of DNA adducts was simplified and improved to increase throughput while maintaining high adduct selectivity. It was demonstrated that the StageTip composed of two sheets of a poly(styrene-divinylbenzene) copolymer disk could be easily prepared and proved useful for selective extraction of trace amounts of DNA adducts from a sample solution containing a great quantity of normal deoxynucleosides.

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عنوان ژورنال:
  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

دوره 30 4  شماره 

صفحات  -

تاریخ انتشار 2014